Stamets’s patent for this formula says measurable results for reversing dementia should come after one year. I noticed a big improvement from using lion’s mane for one month. The patent does not mention any pausing in the formula, it states that the fact that people become less sensitive to psilocybin after a week or two makes the formula “abuse proof”. Other micro-dosers say “3 days on 2 days off.”

https://medium.com/@henziran/stamets-lion-s-mane-niacin-protocol-in-detail-594666d8b216